Terazima M., Kataoka R., Ueoka R., Okamoto Y. (Eds.) Molecular Science of Fluctuations Toward Biological Functions

Springer, Japan, 2016. – 270 p. – ISBN: 4431558381In this monograph, the importance of fluctuations for biological reactions is discussed from various points of view. Understanding the biological reactions at the molecular level is one of the major targets in many scientific fields, including not only basic biology but also physics, physical chemistry, and medical science. One of the key factors in the process is “fluctuation”. Thermal energy causes biological molecules to be in constant fluctuation even while they are carrying out their biological functions. How do biological systems overcome the thermal fluctuations to realize the physiologically relevant reactions? Scientists in a number of fields―physics, chemistry, pharmacology, medicine, and others―have contributed chapters that elucidate the nature of the fluctuations and the relationship between fluctuations and biological functions. The fluctuations discussed in this volume are detected by the transient grating method, nuclear magnetic resonance, X-ray diffraction and scattering, and computer simulation, among other methods. The book presents various results of the studies of fluctuations in biological processes that were obtained with these methods by the leading scientists in their fields.Time-Resolved Detection of Protein Fluctuations During Reactions
Pressure Perturbation: A Prime Tool to Study Conformational Substates and Volume Fluctuations of Biomolecular Assemblies
Watching a Signaling Protein Function in Real Time via Picosecond Time-Resolved Laue Crystallography
NMR Explorations of Biomolecular Systems with Rapid Conformational Exchanges
Site-Specific Incorporation of Fluorescent Nonnatural Amino Acids into Proteins and Its Application to Fluorescence Analysis of Proteins
Unfoldomes and Unfoldomics: Introducing Intrinsically Disordered Proteins
Structure, Dynamics, and Function of Staphylococcal Nuclease
Theory of Molecular Recognition and Structural Fluctuation of Biomolecules
Structural Fluctuations of Proteins in Folding and Ligand Docking Studied by Replica-Exchange Simulations
Spatiotemporal Fluctuations of Protein Folding in Living Cells
Membrane-Targeted Nanotherapy with Hybrid Liposomes for Cancer Cells Leading to Apoptosis
Antitumor Complexes Formed by Oleic Acid and Molten Globule Intermediates of Proteins