Yan Bing (ed.) Analysis and Purification Methods in Combinatorial Chemistry

Chemical analysis. A series of monographs on analytical chemistry and its applications. Vol.
163. - Wiley-Interscience, 2004. - 466 p.
Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable, " and "drugable. "To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering:
* Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis
* High-throughput analytical methods used to analyze the quality of libraries
* High-throughput purification techniques
* Analytical methods applied in post-synthesis and post-purification stagesDrawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques.This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.Analysis for Feasibility and Optimization of Library Synthesis
Quantitative Analysis in Organic Synthesis with NMR Spectroscopy
[superscript 19]F Gel-Phase NMR Spectroscopy for Reaction Monitoring and Quantification of Resin Loading
The Application of Single-Bead FTIR and Color Test for Reaction Monitoring and Building Block Validation in Combinatorial Library Synthesis
HR-MAS NMR Analysis of Compounds Attached to Polymer Supports
Multivariate Tools for Real-Time Monitoring and Optimization of Combinatorial Materials and Process Conditions
Mass Spectrometry and Soluble Polymeric Support
High-Throughput Analysis for Library Quality Control
High-Throughput NMR Techniques for Combinatorial Chemical Library Analysis
Micellar Electrokinetic Chromatography as a Tool for Combinatorial Chemistry Analysis: Theory and Applications
Characterization of Split-Pool Encoded Combinatorial Libraries
High-Throughput Purification to Improve Library Quality
Strategies and Methods for Purifying Organic Compounds and Combinatorial Libraries
High-Throughput Purification: Triage and Optimization
Parallel HPLC in High-Throughput Analysis and Purification
Analysis for Compound Stability and Drugability
Organic Compound Stability in Large, Diverse Pharmaceutical Screening Collection
Quartz Crystal Microbalance in Biomolecular Recognition
High-Throughput Physicochemical Profiling: Potential and Limitations
Solubility in the Design of Combinatorial Libraries
High-Throughput Determination of Log D Values by LC/MS Method