Kalow W., Meyer U.A., Tyndale R.F. (Eds.). Pharmacogenomics

2nd Edition. - Taylor & Francis, 2005. - 658 p. - Reflecting the shift from genetics to genomics in the pharmaceutical sphere, this Second Edition traces the evolution of the science of pharmacogenetics and gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamics, and disease gene identification.Historical Aspects of Pharmacogenetics
Pharmacogenomics and the Promise of Personalized Medicine
Current Status of Pharmacogenomics
Drug Metabolism
Receptors
Pharmacogenetics and Drug Transporters
Variability of Induction Processes
Pharmacogenetics and Cardiac Ion Channels. Interethnic Differences in Drug Response
Clinical Viewpoints
Regulatory Perceptions
Methodologies in Genetics and Genomics
Tools of the Trade: The Technologies and Challenges of Pharmacogenomics
Technologies for the Analysis of Single Nucleotide Polymorphisms
Molecular Diagnostics and Development of Biotechnology-based Diagnostics
Metabonomics
MALDI-TOF MS: Application in Genomics
Measuring Gene Expression: Transcriptional Insights into Functional Biology
From Genotype to Phenotype
Proteomics
Haplotype Structure
Pharmacoepigenetics: From Basic Epigenetics to Therapeutic Applications
Bioinformatics: Aims and Methodologies of a New Discipline
Internet Rsources
Applied Bioinformatics
Genetics of Common Diseases
Mapping of Disease Loci
Positional Cloning and Disease Gene Identification
Genome Variation Influencing Gene Copy Number and Disease
Conclusions
General Conclusions and Future Directions