Lopez-Larrea C. (Ed.). Self and Nonself

Springer, 2012. - 338 p.
In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture Immunological Recognition of Self emphasizing the central argument of immunological tolerance in How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve. The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.The Origin of the Bacterial Immune Response
The Evolution of Self During the Transition to Multicellularity
Glyconectin Glycans as the Self-Assembling Nano-Molecular-Velcrosystem Mediating Self-Nonself Recognition and Adhesion Implicated in Evolution of Multicellularity
Neglected Biological Features in Cnidarians Self-Nonself Recognition
Intracellular Inflammatory Sensors for Foreign Invaders and Substances of Self-Origin
Nonself Perception in Plant Innate Immunity
How Did Flowering Plants Learn to Avoid Blind Date Mistakes? Self-Incompatibility in Plants and Comparisons with Nonself Rejection in the Immune Response
Signaling Pathways that Regulate Life and Cell Death: Evolution of Apoptosis in the Context of Self-Defense
Sensing Necrotic Cells
Sensing Endoplasmic Reticulum Stress
Autophagy and Self-Defense
Viruses and Host Evolution: Virus-Mediated Self Identity
The Evolution of Adaptive Immunity
Epigenetic Code and Self-Identity
Viral Immunomodulatory Proteins: Usurping Host Genes as a Survival Strategy
The Emergence of the Major Histocompatilibility Complex
MHC Signaling During Social Communication