Picken M., Dogan A. Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations

Humana Press, 2012. - 418 p. ISBN: 1607613883Abnormal proteins have been known to be associated with various pathologies. Most notably, these involve amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized deposits. Systemic Amyloid and Related Disorders presents an overview of recent developments in the area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies is also discussed. While the main portion of the text focuses on renal pathology, the involvement of other organ systems, such as cardiac, gastrointestinal and pulmonary pathology is also covered. This approach provides a unifying concept of these pathologic processes, which appear to have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to renal pathologists, cardiac pathologists, gastro-intestinal pathologists and general pathologists.Introduction/General :
Aspects of the History and Nomenclature of Amyloid and Amyloidosis
Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis
AA Amyloidosis
The Hereditary Amyloidoses
Dialysis-Associated Amyloidosis
Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System
Cerebrovascular Amyloidoses
Non-Amyloid Protein Deposits:
Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Material in the Differential Diagnosis of Amyloidosis
Light / Heavy Chain Deposition Disease as a Systemic Disorder
Glomerulonephritis with Non-Organized Monoclonal Immunoglobulin Deposits
Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond
Diagnosis :
Diagnosis of Amyloid Using Congo Red
Diagnosis of Minimal Amyloid Deposits using the Congo Red Fluorescence Method - A Review
Thioflavin T stain - An Easier and More Sensitive Method for Amyloid Detection
Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis
Generic Diagnosis of Amyloid – a Summary of Current Recommendations and the Editorial Comments on Chapters 12 - 15
Routine Use of Amyloid Typing on Formalin-fixed Paraffin Sections from 626 Patients by Immunohishemistry
Amyloid Typing – Experience from a Large Referral Centre
Options for Amyloid Typing in Renal Pathology – the Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations for Immunohishemistry
Amyloid Typing: Immuno-Electron Microscopy
Classification of Amyloidosis by Mass Spectrometry Based Proteomics
Ancillary Studies of Amyloidosis :
Laboratory Support for Diagnosis of Amyloidosis
Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias
Laboratory Methods for the Diagnosis of Hereditary Amyloidoses
Organ Involvement in Amyloidoses :
Amyloidoses of the Kidney and Genitourinary Tract
Cardiac Amyloidoses
Amyloidosis of the Gastrointestinal Tract and Liver
Peripheral Nerve Amyloidosis
Clinical Issues and Therapy :
Clinical and Pathologic Issues in Patients with Amyloidosis – Practical Comments Regarding Diagnosis, Therapy and Solid Organ Transplantation
Emerging Therapies for Amyloidosis
Modern Therapies in AA Amyloidosis
Medicolegal Issues of Amyloidosis
Amyloidosis from the Patient’s Perspective