Swartz Michael E. (ed.). Analytical techniques in combinatorial chemistry

Marcel Dekker, Inc.,
200. – 301 p.6000 known drugs fall into only around 300 chemical classes (the exact figure depends on how one defines a ‘‘class’’). Recently, a major pharmaceutical company screened its entire compound inventory - over 400,000 compounds developed over almost 100 years of work - against a new target identified by genomics. They did not find a single hit. This sounds surprising until one examines that inventory closely: almost half the compounds in it could be considered to be derived from a single chemical class.
It is this problem that combinatorial chemistry is designed to solve, and its explosive growth is testimony to both the magnitude of the problem and the early successes of the combinatorial approach.
Analytical Techniques in Combinatorial Chemistry is intended to provide specific details on how analytical techniques are brought to bear on the unique challenges presented in the combinatorial chemistry laboratory. It is aimed primarily at industrial and pharmaceutical chemists faced with the task of developing methods, analyzing the results, and documenting and/or managing the discovery process in a combinatorial setting. Since many major pharmaceutical companies are in the process of staffing combinatorial chemistry departments, this publication could also serve as a training and reference source, or perhaps a graduate-level textbook. While the book is not intended to be an exhaustive literature review, specific citations are examined that highlight the use of analytical techniques and the way in which they are utilized to solve the unique problems encountered. It presents a basic introduction to the field for a novice, while providing detailed information sufficient for an expert in a particular analytical techique.Following the introduction presented in Chapter 1, this book discusses the application and use of specific analytical techniques (mass, infrared, and nuclear magnetic resonance spectrometry, chromatography, and capillary electrophoresis) in the combinatorial chemistry field (Chapters 2–6). It also discusses how to make sense of the vast amounts of data generated (Chapter 7), details how the actual libraries of compounds produced are utilized (Chapter 8), and lists some of the vast commercial resources available to researchers in the field of combinatorial chemistry (Chapter 9).An Introduction to Combinatorial Chemistry
The Use of Mass Spectrometry
Infrared and Raman Spectroscopy
NMR Methods
The Role of Liquid Chromatography
Capillary Electrophoresis in Combinatorial Library Analysis
Finding a Needle in a Haystack: Information Management for High-Throughput Synthesis of Small Organic Molecules
Bioanalytical Screening Methodologies for Accelerated Lead Generation and Optimization in Drug Discovery
Commercial Resources